كتاب مقاله (2013)Protein tyrosine phosphatases as novel targets in breast cancer therapy

چكيده : 

Breast cancer is linked to hyperactivation of protein tyrosine kinases (PTKs), and recent studies have unveiled

that selective tyrosine dephosphorylation by protein tyrosine phosphatases (PTPs) of specific substrates,

including PTKs, may activate or inactivate oncogenic pathways in human breast cancer cell growth-related

processes. Here, we review the current knowledge on the involvement of PTPs in breast cancer, as major

regulators of breast cancer therapy-targeted PTKs, such as HER1/EGFR, HER2/Neu, and Src. The functional

interplay between PTKs and PTK-activating or -inactivating PTPs, and its implications in novel breast cancer

therapies based on targeting of specific PTPs, are discussed.